Where delivery transforms treatment

Explore Our Science

The therapy isn’t just the gene — it's also the vehicle

Revolutionizing AAV (Adeno-Associated Virus) Gene Therapy through capsid engineering and optimized routes of administration.

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Pursuing Efficacy

Striving to increase substructure– and cell-specific targeting.

Prioritizing Well-Being

Aiming to limit or avoid on– and off-tissue toxicity.

Optimizing Delivery

Lowering dose requirements and costs associated with manufacturing and clinical deployment.

Transforming Disease Treatment with One-Time Gene Therapy

19% of people globally are affected by monogenic diseases, yet many go untreated due to the absence of effective therapies. Our innovative gene therapy approach aims to revolutionize treatment and bring hope to millions.

19% of people globally have monogenic disease

While AAV gene therapy is tailor-made to enable potentially curative treatments for genetically defined disease, several challenges persist

By identifying more potent and specific AAV capsid variants, Latus aims to enable low-dose gene therapies at lower costs, with improved manufacturing efficiency, and with enhancements in both efficacy and safety.

Unlocking the Power of AAV Gene Therapy

We’re seeking to advance the standard
for precision gene therapy

By deploying advanced computational methods and unbiased screening directly in NHP's - we're mapping the future of delivery for genetic medicines. Designed to accurately target tissues and reduce unwanted interactions, our technology aims to minimize the risks of immunogenicity and toxicity, delivering the payload exactly where it's needed.

Our one-time gene therapy candidates are designed to fundamentally change how many diseases are treated.

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Our proprietary platforms enable massively-paralleled and unbiased screening of AAV capsid variant libraries directly in non-human primates (NHPs)

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Identify Disease- and Target-specific Substructure
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Select Optimal Route for Clinical Administration (RoA)
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Screen for Novel Tissue- and Cell-specific Capsids via Optimal ROA in NHPs
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Engineer Specific Payload Expression Using Proprietary Promoters and Regulatory Elements

We identify novel AAV capsid variants with substructure- and cell-type specificity matched to optimal routes of administration (RoAs)

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Deep Brain
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Ependyma
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Ear
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Pan-Neuronal
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Eye
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muscle
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Heart
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kidney

Our novel AAV capsid variants have the potential to unlock significant clinical benefit and commercial upside

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Our Novel Capsid Variants Aim to Enable One- time Gene Therapies to Treat an Unprecedented Number of Diseases

By developing more potent AAVs, our candidates are being designed to provide improved efficacy at low doses, potentially improving costs, manufacturing efficiency and patient safety.

Problems with AAV (high COGS, toxicity, variable efficacy) stem from high dose requirements

Latus reduces aav doses via direct routes of administration (RoA) and engineering capsids with disease-specific tropism

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Explore Differentiation

The specificity of our capsid variants enables targeting a broad range of central nervous system (CNS) and peripheral diseases.

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“I really hope we can find a way to slow down this disease. No parent wants to see their kid go through endless hospital visits, the pain of treatments, or spend their days in a hospital bed. We just want more happy, normal days at home, more laughter, and less tears—more time being a family without the constant stress of medical issues.”

—Caregiver

CLN2 Disease

“Huntngton's Disease remains a devastating, incurable genetic brain disease, for which we desperately need effective interventions. A breakthrough would be transformative for affected patients and families worldwide.”

—HD Clinician

Huntington’s Disease

Our candidates are being designed to meaningfully reduce toxicity and improve quality of care for patients.

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AAV gene transfer delays disease onset in a TPP1-deficient canine model of the late infantile form of Batten disease

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Targeted long-read sequencing captures CRISPR editing and AAV integration outcomes in brain

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Targeted long-read sequencing captures CRISPR editing and AAV integration outcomes in brain

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Translational medicine expertise that spans from pipette to patient

Our team comprises industry-leading scientists, world-class clinicians and seasoned industry executives who are dedicated to revolutionizing gene therapy.

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